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Articles (43)
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Therapeutic Oligonucleotides: State of the Art

Smith, C.I. Edvard, Zain, Rula

Journal:

Annual Review of Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2019

Triple-Helix Directed Cleavage of Double-Stranded DNA by Benzoquinoquinoxaline-1,10-phenanthroline Conjugates

Ahmed Zaid, Jian-Sheng Sun, Chi-Hung Nguyen, Emile Bisagni, Thérèse Garestier, David S. Grierson, Rula Zain

Journal:

ChemBioChem

Année:

2004

Langue:

english

Fichier:

PDF, 338 KB

english, 2004

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Xu, You, Gissberg, Olof, Pabon-Martinez, Y. Vladimir, Wengel, Jesper, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra, Salsbury, Freddie

Journal:

PLoS ONE

Année:

2019

Langue:

english

Fichier:

PDF, 2.15 MB

english, 2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) || Chemical Development of Therapeutic Oligonucleotides

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Langue:

english

Fichier:

PDF, 340 KB

english, 2019

Optimization of Triple-Helix-Directed DNA Cleavage by Benzoquinoquinoxaline–Ethylenediaminetetraacetic Acid Conjugates

Rula Zain, David Polverari, Chi-Hung Nguyen, Yves Blouquit, Emile Bisagni, Thérèse Garestier, David S. Grierson, Jian-Sheng Sun

Journal:

ChemBioChem

Année:

2003

Langue:

english

Fichier:

PDF, 172 KB

english, 2003

Structure-Specific Recognition of Friedreich's Ataxia (GAA)n Repeats by Benzoquinoquinoxaline Derivatives

Helen Bergquist, Abbas Nikravesh, Raquel Domingo Fernández, Veronica Larsson, Chi-Hung Nguyen, Liam Good, Rula Zain

Journal:

ChemBioChem

Année:

2009

Langue:

english

Fichier:

PDF, 552 KB

english, 2009

A new entry to nucleoside phosphorofluoridate and nucleoside phosphorofluoridothioate diesters

Martin Bollmark, Rula Zain, Jacek Stawiński

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 243 KB

english, 1996

Stereospecific oxidation and oxidative coupling of H-phosphonate and H-phosphonothioate diesters

Jacek Stawiński, Roger Strömberg, Rula Zain

Journal:

Tetrahedron Letters

Année:

1992

Langue:

english

Fichier:

PDF, 287 KB

english, 1992

Nucleoside H-phosphonates. X. Studies on nucleoside hydrogenphosphonothioate diester synthesis

Jacek Stawiński, Mats Thelin, Rula Zain

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 309 KB

english, 1989

Design of a triple-helix-specific cleaving reagent

Rula Zain, Christophe Marchand, Jian-sheng Sun, Chi Hung Nguyen, Emile Bisagni, Thérèse Garestier, Claude Hélène

Journal:

Chemistry & Biology

Année:

1999

Langue:

english

Fichier:

PDF, 149 KB

english, 1999

Nucleoside H-phosphonates. Part 16. 31P NMR studies on the transformation of nucleoside H-phosphonate monoesters into a monofunctional tervalent intermediate, nucleoside acyl silyl phosphite

Zain, Rula, Stawi?ski, Jacek

Journal:

Journal of the Chemical Society Perkin Transactions 2

Année:

1996

Langue:

english

Fichier:

PDF, 827 KB

english, 1996

Benzoquinoquinoxaline Derivatives Stabilize and Cleave H-DNA and Repress Transcription Downstream of a Triplex-forming Sequence

Haleh Amiri, Natalia Nekhotiaeva, Jian-Sheng Sun, Chi-Hung Nguyen, David S. Grierson, Liam Good, Rula Zain

Journal:

Journal of Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 322 KB

english, 2005

Nucleoside H-phosphonates. 12. Synthesis of nucleoside 3'-(hydrogen phosphonothioate) monoesters via phosphinate intermediates

Stawinski, Jacek, Thelin, Mats, Westman, Erik, Zain, Rula

Journal:

Journal of Organic Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 560 KB

english, 1990

Nucleoside H-Phosphonates. 15. Preparation of Nucleoside H-Phosphonothioate Monoesters from the Corresponding Nucleoside H-Phosphonates

Zain, Rula, Stroemberg, Roger, Stawinski, Jacek

Journal:

Journal of Organic Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 583 KB

english, 1995

Nucleoside H-Phosphonates. 17. Synthetic and 31 P NMR Studies on the Preparation of Dinucleoside H-Phosphonothioates

Zain, Rula, Stawiński, Jacek

Journal:

Journal of Organic Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 202 KB

english, 1996

Antisense PNA Accumulates in Escherichia coli and Mediates a Long Post-antibiotic Effect

Nikravesh, Abbas, Dryselius, Rikard, Faridani, Omid R, Goh, Shan, Sadeghizadeh, Majid, Behmanesh, Mehrdad, Ganyu, Anita, Klok, Erik Jan, Zain, Rula, Good, Liam

Journal:

Molecular Therapy

Année:

2007

Langue:

english

Fichier:

PDF, 382 KB

english, 2007

Studies on Nucleoside H-Phosphonothioates as Synthons in the Synthesis of Oligonucleotide Analogues

Zain, Rula, Bollmark, Martin, Stawinski, Jacek

Journal:

Nucleosides and Nucleotides

Année:

1997

Langue:

english

Fichier:

PDF, 123 KB

english, 1997

Conversion of Nucleoside H-Phosphonate Monoesters to the Corresponding H-Phosphonothioates. 31P NMR Studies

Stawinski, Jacek, Zain, Rula

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

1995

Langue:

english

Fichier:

PDF, 251 KB

english, 1995

Studies on the Conversion of Nucleoside H-Phosphonate Monoesters into the Corresponding H-Phosphonothioates

Stawinski, Jacek, Stromberg, Roger, Zain, Rula

Journal:

Nucleosides and Nucleotides

Année:

1991

Langue:

english

Fichier:

PDF, 120 KB

english, 1991

Nucleoside Phosphonates. Development of Synthetic Methods and Reagents

Kers, Annika, Kers, Inger, Kraszewski, Adam, Sobkowski, Michal, Szabó, Tomas, Thelin, Mats, Zain, Rula, Stawinski, Jacek

Journal:

Nucleosides Nucleotides & Nucleic Acids

Année:

1996

Langue:

english

Fichier:

PDF, 892 KB

english, 1996

A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase

Guo, Manhong, Hundseth, Kristian, Ding, Hao, Vidhyasagar, Venkatasubramanian, Inoue, Akira, Nguyen, Chi-Hung, Zain, Rula, Lee, Jeremy S., Wu, Yuliang

Journal:

Journal of Biological Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 4.44 MB

english, 2015

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs

Gissberg, Olof, Zaghloul, Eman M., Lundin, Karin E., Nguyen, Chi-Hung, Landras-Guetta, Corinne, Wengel, Jesper, Zain, Rula, Smith, C.I. Edvard

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Année:

2016

Langue:

english

Fichier:

PDF, 516 KB

english, 2016

Clamping of RNA with PNA enables targeting of microRNA

Ghidini, Alice, Bergquist, Helen, Murtola, Merita, Punga, Tanel, Zain, Rula, Strömberg, Roger

Journal:

Organic & Biomolecular Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 948 KB

english, 2016

Studies on Nucleoside Phosphonates and Their Derivatives. a Progress Report

Bollmark, Martin, Kers, Annika, Kers, Inger, Szabó, Tomas, Zain, Rula, Stawiński, Jacek, Cieślak, Jacek, Jankowska, Jadwiga, Kraszewski, Adam

Journal:

Nucleosides and Nucleotides

Année:

1997

Langue:

english

Fichier:

PDF, 436 KB

english, 1997

Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity

Rocha, Cristina S.J., Lundin, Karin E., Behlke, Mark A., Zain, Rula, EL Andaloussi, Samir, Smith, C.I. Edvard

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Année:

2016

Langue:

english

Fichier:

PDF, 806 KB

english, 2016

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

Hartono, Yossa Dwi, Pabon-Martinez, Y. Vladimir, Uyar, Arzu, Wengel, Jesper, Lundin, Karin E., Zain, Rula, Smith, C. I. Edvard, Nilsson, Lennart, Villa, Alessandra

Journal:

ACS Omega

Année:

2017

Langue:

english

Fichier:

PDF, 5.09 MB

english, 2017

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression

Zaghloul, Eman M., Gissberg, Olof, Moreno, Pedro M.D., Siggens, Lee, Hällbrink, Mattias, Jørgensen, Anna S., Ekwall, Karl, Zain, Rula, Wengel, Jesper, Lundin, Karin E., Smith, C.I. Edvard

Journal:

Nucleic Acids Research

Année:

2017

Langue:

english

Fichier:

PDF, 12.28 MB

english, 2017

Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)n Repeats by PNA or LNA Targeting

Bergquist, Helen, Rocha, Cristina S. J., Álvarez-Asencio, Rubén, Nguyen, Chi-Hung, Rutland, Mark. W., Smith, C. I. Edvard, Good, Liam, Nielsen, Peter E., Zain, Rula, Veedu, Rakesh N.

Journal:

PLoS ONE

Année:

2016

Langue:

english

Fichier:

PDF, 4.83 MB

english, 2016

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity

Saher, Osama, Rocha, Cristina S.J., Zaghloul, Eman M., Wiklander, Oscar P.B., Zamolo, Susanna, Heitz, Marc, Ezzat, Kariem, Gupta, Dhanu, Reymond, Jean-Louis, Zain, Rula, Hollfelder, Florian, Darbre, T

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2018

Langue:

english

Fichier:

PDF, 2.96 MB

english, 2018

Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression

Fathi, Narmeen N., Mohammad, Dara K., Görgens, André, Andaloussi, Samir EL., Zain, Rula, Nore, Beston F., Smith, C.I. Edvard

Journal:

Biochemical and Biophysical Research Communications

Année:

2018

Langue:

english

Fichier:

PDF, 529 KB

english, 2018

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Xu, You, Gissberg, Olof, Pabon-Martinez, Y. Vladimir, Wengel, Jesper, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra, Salsbury, Freddie

Journal:

PLoS ONE

Année:

2019

Fichier:

PDF, 2.15 MB

2019

Oligonucleotide Binding to Non-B-DNA in MYC

Umek, Tea, Sollander, Karin, Bergquist, Helen, Wengel, Jesper, Lundin, Karin E., Smith, C.I. Edvard, Zain, Rula

Journal:

Molecules

Année:

2019

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2019

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

Hande, Madhuri, Saher, Osama, Lundin, Karin, Smith, C., Zain, Rula, Lönnberg, Tuomas

Journal:

Molecules

Année:

2019

Fichier:

PDF, 1.10 MB

2019

Targeted Oligonucleotides for Treating Neurodegenerative Tandem Repeat Diseases

Zain, Rula, Smith, C. I. Edvard

Journal:

Neurotherapeutics

Année:

2019

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) || Identifying Suitable Target Regions and Analyzing Off-Target Effects of Therapeutic Oligonucleotides

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Langue:

english

Fichier:

PDF, 669 KB

english, 2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) || Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Langue:

english

Fichier:

PDF, 528 KB

english, 2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) || Antisense Oligonucleotides for Splice Modulation: Assessing Splice Switching Efficacy

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Fichier:

PDF, 340 KB

2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) ||

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Fichier:

PDF, 8.79 MB

2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) || Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Fichier:

PDF, 359 KB

2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) || In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Fichier:

PDF, 403 KB

2019

[Methods in Molecular Biology] Oligonucleotide-Based Therapies Volume 2036 (Methods and Protocols) || Evaluation of Cell-Penetrating Peptide Delivery of Antisense Oligonucleotides for Therapeutic Efficacy in Spinal Muscular Atrophy

Gissberg, Olof, Zain, Rula, Lundin, Karin E.

Année:

2019

Fichier:

PDF, 606 KB

2019

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

Saher, Osama, Lehto, Taavi, Gissberg, Olof, Gupta, Dhanu, Gustafsson, Oskar, Andaloussi, Samir EL, Darbre, Tamis, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula

Journal:

Pharmaceutics

Année:

2019

Fichier:

PDF, 5.05 MB

2019

Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects

EstupiÃ±Ã¡n, H. Yesid, Bouderlique, Thibault, He, Chenfei, BerglÃ¶f, Anna, Gupta, Dhanu, Saher, Osama, Daza Cruz, Miguel Ãngel, PeÃ±a-Perez, Lucia, Yu, Liang, Zain, Rula, Karlsson, Mikael C. I., MaÌ

Journal:

Blood Advances

Année:

2020

Fichier:

PDF, 1.85 MB

2020